Sildenafil 50 mg: Onset of Action and Peak Effect
While you may see product availability reduction in the near-term, please be assured that we at McGuff Medical are continuing to work diligently to ensure an uninterrupted supply of products and alternative products to you. Additionally, in order to ensure healthcare providers have access to the PPEs they need, the McGuff Company is temporarily limiting PPEs to healthcare providers. As always, please feel free to reach out to our McGuff Customer Service team with any questions that you may have. Sildenafil is commonly used for the following conditions. Erectile dysfunction, a condition where you have trouble getting or keeping an erection Pulmonary arterial hypertension, sildenafil citrate tablet a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs Sildenafil may also be used for other conditions as determined by your healthcare provider.
| Attribute | Description | Notes |
|---|---|---|
| Active Ingredient | Sildenafil citrate | 50 mg per tablet |
| Mechanism of Action | PDE5 enzyme inhibition to promote vasodilation | Enhances blood flow for erectile function |
| Onset of Action | 30-60 minutes | Varies with food intake |
| Duration of Effect | Up to 4-6 hours | Effect duration can vary |
| Metabolism | Primarily processed in the liver through CYP3A4 and CYP2C9 enzymes | Potential drug interactions |
| Contraindications | Use with nitrates or contraindicated in severe cardiovascular conditions | Precautions required |
Sildenafil works by blocking an enzyme in the body called PDE5, which helps relax certain blood vessels. For erectile dysfunction, it increases blood flow to the penis when aroused. This makes it easier to get and keep an erection. For pulmonary arterial hypertension, sildenafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart. 10 mg/mL powder for oral suspension 20 mg, 25 mg, 50 mg, 100 mg oral tablets Sildenafil is also available in an injectable form that is usually given by a healthcare provider in a hospital or clinic.
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This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.
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The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. If you can't find what you were looking for, please contact us using one of the methods below so we can better serve you. Due to the Coronavirus (COVID-19) outbreak worldwide, the global demand for some Personal Protective Equipment (PPE) is exceeding current supply availability. In addition, the manufacturing of the PPE and many other wound care/infection prevention products have been impacted by the global response to the Coronavirus. Sildenafil oral tablets should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Sildenafil oral liquid should be stored at room temperature below 86 F (30 C) or in the refrigerator, between 36 F to 46 F (2 C to 8 C).
| Product | Dosage | Quantity + Bonus | Price | |
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Throw away any remaining liquid 60 days after it has been mixed for you by a pharmacist or healthcare professional.
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If this serious problem occurs, stop taking sildenafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke. Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Stop taking sildenafil and get medical help right away if these effects occur. Rarely, males may have a painful or prolonged erection lasting 4 or more hours.
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If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: itching/swelling (especially of the face/tongue/throat) This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects.
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You may report side effects to Health Canada at 1-866-234-2345. Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure) penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease) conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma) eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION) This drug may make you dizzy or cause vision problems. Sildenafil injection is usually given by a healthcare provider in a hospital or clinic. You will not store it at home. The most common side effects of sildenafil are listed below.
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Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). During pregnancy, sildenafil should be used only when clearly needed.
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Since high blood pressure in the lungs is a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
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Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: Sildenafil can cause a serious drop in your blood pressure when used with nitrates. A serious drop in blood pressure can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use sildenafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide) recreational drugs called "poppers" containing amyl or butyl nitrite If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure. These side effects may vary depending on the condition that is being treated.
- Sildenafil 50 mg is part of PDE5 inhibitor class.
- It may improve quality of life for men with ED.
- Avoid taking it if you have a recent heart attack.
- Be aware of potential priapism, a rare prolonged erection.
- Use with caution if you have low blood pressure.
- Review all medications with your healthcare provider.
- The medication does not cause dependency.
- Check product labels and consult pharmacists if unsure.
Tell your healthcare provider if you have any of these side effects that bother you.
| Patient Group | Recommended Dosage | Administration Timing | Special Considerations |
|---|---|---|---|
| Adult Men with ED | 50 mg as needed | 30 to 60 minutes before sexual activity | Adjust based on efficacy and tolerability |
| Elderly Patients | Same as adults, starting with lower dose | 50 mg usually appropriate | Monitor for side effects |
| Patients with Liver Impairment | Consult healthcare provider | Dose adjustments may be necessary | Increased risk of side effects |
| Patients on CYP3A4 inhibitors | Lower dose recommended | Due to increased drug levels | e.g., ketoconazole, ritonavir |
Pain in your muscles, back, arms, or legs There may be other side effects of sildenafil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345. While less common, the most serious side effects of sildenafil are described below, along with what to do if they happen.
- Always take sildenafil with a full glass of water.
- Use the medication responsibly to avoid dependency.
- Do not share your medication with others.
- Regular check-ups are recommended during use.
- Report any vision or hearing disturbances immediately.
- Use caution if combining with antihypertensive drugs.
- It is not intended for use in erectile enhancement alone.
- Follow legal and medical guidelines for purchase.
Sildenafil may cause allergic reactions, which can be serious. Stop taking sildenafil and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Sildenafil can cause side effects like dizziness.
- Use with caution if you have liver or kidney issues.
- The medication may cause vision changes or blurriness.
- Take sildenafil on an empty stomach for quicker effect.
- Follow your doctor’s dosage instructions strictly.
- Overdose may lead to serious health complications.
- Avoid driving or operating machinery after taking.
- Use only the prescribed strength, 50 mg.
Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red bumps on the skin called hives Sildenafil may cause an unwanted erection that is persistent, painful, and that may occur without sexual arousal. Permanent damage to the penis may occur if priapism is not treated quickly.
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Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others. Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.
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US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: severe dizziness, fainting, sildenafil pick up painful/prolonged erection. Do not share this medication with others. Store at room temperature away from light and moisture.
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Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Stop taking sildenafil and get emergency help if you have any of the following symptoms of priapism. Erection lasting for more than four hours Erection that is unrelated to sexual stimulation Sildenafil can cause mild, temporary vision changes such as seeing a blue tint, abnormal colors, blurry vision, or sensitivity to light.
