How Sildenafil Citrate Works in the Body
This will increase the supply of blood to the lungs and reduce the workload of the heart.
Other uses for this medicine
This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. Sildenafil is used to treat erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. This medicine is available only with your doctor's prescription.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Polo | 100mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
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This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
| Condition | Ideal Range | Additional Notes |
|---|---|---|
| Temperature | 15°C to 30°C | Avoid extreme heat or cold |
| Humidity | Low humidity | Keep in dry place |
| Light | Keep away from direct sunlight | Protect from light |
| Packaging | Original packaging, airtight | Prevent moisture exposure |
This is a decision you and your doctor will make.
| Age Range | Suitability | Notes |
|---|---|---|
| 18-50 years | Usually suitable | Under doctor supervision |
| 51-70 years | Caution advised | Dose adjustment may be needed |
| Over 70 years | Use with caution | Potential drug interactions |
For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
What special precautions should I follow?
Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: itching/swelling (especially of the face/tongue/throat) This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Other Medical Problems
You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
What are the most common side effects of sildenafil?
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure) penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease) conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma) eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION) This drug may make you dizzy or cause vision problems. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.
Metrics & Citations
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if your condition does not get better. Dizziness, headache, flushing, or stomach upset may occur. Vision changes such as increased sensitivity to light, blurred vision, or trouble telling blue and green colors apart may also occur.
How does sildenafil work (mechanism of action)?
If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Sexual activity may put extra strain on your heart, especially if you have heart problems.
Raynaud's phenomenon
If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: Rarely, sudden decreased vision, or even permanent blindness, may occur in one or both eyes (NAION). If this serious problem occurs, stop taking sildenafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke. Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Stop taking sildenafil and get medical help right away if these effects occur. For non-prescription products, read the label or package ingredients carefully.
| Advice Item | Explanation | Source |
|---|---|---|
| Take on an empty stomach | Food, especially fatty meals, can delay absorption | Medical guidelines |
| Avoid alcohol | Can impair effectiveness and increase side effects | Doctor advice |
| Do not exceed prescribed dose | Increased risk of side effects | Pharmaceutical recommendation |
| Report unexpected side effects | Such as vision changes, prolonged erections | Healthcare provider |
Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age.
Proper Use
During pregnancy, sildenafil should be used only when clearly needed. Since high blood pressure in the lungs is a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
Pulmonary Arterial Hypertension
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: Sildenafil can cause a serious drop in your blood pressure when used with nitrates. A serious drop in blood pressure can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use sildenafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide) recreational drugs called "poppers" containing amyl or butyl nitrite If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting.
Oral Administration
Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure. Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others. Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Safety and efficacy have not been established.
- Sildenafil is a popular choice for men seeking non-invasive ED therapy.
- It's important to have realistic expectations about sildenafil's effects.
- The medication does not increase libido but improves blood flow.
- Patients should limit alcohol consumption when using sildenafil.
- It is recommended to consult a doctor if ED persists despite medication.
- Sildenafil can be used as part of a comprehensive ED treatment plan.
- The medication should be taken approximately an hour before planned activity.
- Some patients experience no side effects at prescribed doses.
- Always confirm that sildenafil is stored properly to maintain efficacy.
- Report any unusual symptoms, such as chest pain or vision loss, immediately.
Sildenafil should never be used in children for erectile dysfunction.
- Sildenafil may improve confidence and sexual satisfaction in men with ED.
- The medication is also being researched for pulmonary hypertension treatment.
- Common side effects include dizziness, upset stomach, and vision changes.
- Rare side effects can include priapism, a painful prolonged erection.
- Alcohol can interfere with sildenafil's effectiveness and increase side effects.
- Patients should disclose any heart conditions before using sildenafil.
- Sildenafil may interact with other medications such as alpha-blockers.
- It is not suitable for individuals with severe liver or kidney problems.
- Taking large doses does not necessarily improve efficacy and increases risk.
- Always follow the prescribed dosage and discontinue if adverse effects occur.
In general, sildenafil should not be used for pulmonary arterial hypertension in children, especially for chronic use.
- Sildenafil has been shown to aid men with diabetes-related ED.
- The drug may also reduce blood pressure temporarily.
- Some men may not respond to sildenafil due to various health factors.
- It is recommended to take sildenafil on an empty stomach for faster effects.
- Overdose symptoms include dizziness, fainting, and pain in the chest.
- Sildenafil should not be used with other erectile dysfunction medications simultaneously.
- Patients should inform their doctor if they experience prolonged erections.
- Certain medical conditions require cautious use of sildenafil.
- The medication can sometimes cause changes in color perception.
- Always check the expiration date before using sildenafil pills.
Use of sildenafil oral film is not indicated for use in the pediatric population.
Sildenafil for ED
Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly.
More about sildenafil
These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil.
Brand names
Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: severe sildenafil oral solution dizziness, fainting, painful/prolonged erection. Do not share this medication with others.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Store at room temperature away from light and moisture. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Mechanism of Action
HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019.
