Backed By Science

“The Role of Local Vaginal Estrogen for Treatment of Vaginal Atrophy in Postmenopausal Women.” Menopause, vol. “Vaginal Estrogen Use and Chronic Disease Risk in the Nurses' Health Study.” Menopause, vol. DARE to PLAY is a topical sildenafil cream enhancing female arousal, available in select states as a compounded product while awaiting FDA approval. Clinical trials showed improved arousal sensation scores, though not statistically significant compared to placebo, with significant benefits in a subset of women with FSAD.

• The effectiveness of Viagra cream depends on skin absorption.
• It is sometimes promoted as a natural alternative.
• Possible benefits include reduced frequency of side effects.
• Scientific evidence supporting its use is limited.
• Users should be wary of false advertising claims.
• Some formulations may contain unsafe or unregulated ingredients.
• Proper use involves cleaning the application area thoroughly.
• The cream should be applied as per product instructions.
• Do not exceed recommended dosage to avoid irritation.
• Keep out of reach of children and pets.

Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026.

Other Scream Cream Ingredients That Boost Libido

It’s a question that sexual medicine researchers have puzzled over since at least the late 1990s, when the Food and Drug Administration approved sildenafil, known as Viagra, for men. Doctors prescribe sildenafil off-label to some female patients, either in the form of low doses of the pill or as a topical cream made by compounding pharmacies. Telehealth companies, like Alloy and Wisp, sell the creams on their platforms. Daré, a pharmaceutical company, is in the process of seeking approval from the F.D.A. for its topical sildenafil cream, which it plans to market specifically to women.

Plast Reconstr Surg

Yet the research, including a study from Daré out today, suggests that if the drug is at all effective at increasing arousal in women, it’s only likely to do so for a small subset. During menopause and perimenopause, many women experienced diminished or less intense orgasms. Topical sildenafil increases blood flow to wherever you apply it (in this case, your clitoris or labia), and increased blood flow leads to increased sensation. Sildenafil: Increases blood flow, stimulates natural lubrication, and heightens physical sensations leading to a stronger, more fulfilling orgasm. In a 2002 study, sildenafil was found to be effective in enhancing vaginal engorgement in healthy premenopausal women. DARE to PLAY, a proprietary topical arousal cream designed to enhance genital blood flow and arousal response in women, can now be prescribed in select states, manufacturer Daré Bioscience, Inc announced in a news release.1 “When Viagra [sildenafil citrate] was approved in 1998, it revolutionized sexual medicine for men. But for women, comparable progress on enhancing the natural arousal sensations has stalled for nearly 3 decades,” said Sabrina Martucci Johnson, President and CEO of Daré Bioscience, in the news release.

• Viagra cream might offer more control over dosing.
• It is often marketed to men seeking non-pill options.
• Some users report increased confidence with topical application.
• The cream is designed for convenience and discreetness.
• It may be combined with lubricants for comfort.
• Skin sensitivity varies, so patch testing is advised.
• The onset of action can be faster than oral forms.
• Interaction with other topical products is unknown.
• Not a cure for sexual dysfunction—only temporary enhancement.
• Consult a healthcare provider about underlying causes of ED.

“We believe DARE to PLAY represents a long overdue correction, giving women an option to reconnect with their own bodies, their pleasure, and their confidence, using science that finally recognizes their needs.”1 As the company continues the process viagra over the counter to seek FDA approval of the sildenafil cream formulation, it is making the cream available in the form of a Section 503B compounded product.

Step	Action	Details	Tips
1	Clean the skin surface	Use mild soap and water	Dry thoroughly before application
2	Apply a thin layer	Use a pea-sized amount	Avoid excess use
3	Massage gently into skin	Ensure even distribution	Wait 10 minutes before activity
4	Wash hands afterward	To prevent accidental transfer	Use gloves if sensitive skin

Although the sildenafil cream is manufactured “in an outsourcing facility subject to FDA inspection and under current Good Manufacturing Practice regulations,” Daré Bioscience noted that compounded drugs are not FDA approved or evaluated by the agency for “safety, effectiveness, or quality.”1 DARE to PLAY is currently available for prescription for pre-order in Connecticut, Florida, Indiana, Missouri, New Jersey, Oregon, Pennsylvania, Rhode Island, and Utah. Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026.1 DARE to PLAY has been evaluated in several studies, including a phase 2b randomized controlled trial (NCT04948151), the results of which were published in Obstetrics & Gynecology.

• Viagra cream is often used by men seeking a discreet option.
• It is a semi-liquid formulation that enhances intimacy.
• The cream may be combined with other topical agents.
• Its shelf life depends on storage conditions.
• Usually available through online vendors, sometimes unregulated.
• The safety and efficacy of Viagra cream are not FDA-approved.
• Users should consult a healthcare provider before use.
• Possible side effects include skin irritation or headache.
• The dosage can vary depending on the product formulation.
• Use with caution if taking nitrates or other medications.

In that study, 200 women with female sexual arousal disorder (FSAD) were randomly assigned to receive the sildenafil cream or placebo cream. The co-primary efficacy end points included change from baseline to week 12 in the Arousal Sensation domain of the Sexual Function Questionnaire (SFQ28), as well as question 14 of the Female Sexual Distress Scale—Desire, Arousal, Orgasm (FSDS-DAO).2 Greater improvement in SFQ28 Arousal Sensation domain scores was observed in patients receiving sildenafil cream, although “there were no statistically significant differences between sildenafil and placebo cream users in the coprimary and secondary efficacy end points,” wrote the authors. The investigators also conducted an exploratory post hoc analysis evaluating a subset of the intention-to-treat population who had a diagnosis of FSDD with or without concomitant decreased desire.

Product	Dosage	Quantity + Bonus	Price
Viagra Generic	50mg	60 + 4 Pills	83.93€ 79.93€	Buy
Viagra Super Active	100mg	20 + 4 Pills	48.05€ 45.76€	Buy
Viagra Generic	50mg	270 + 8 Pills	198.48€ 189.03€	Buy
Viagra Professional	100mg	90 + 2 Pills	207.09€ 197.23€	Buy
Viagra Generic	25mg	90 + 6 Pills	105.03€ 100.03€	Buy
Viagra Generic	25mg	20 Pills	37.74€ 35.94€	Buy
Viagra Original	100mg	8 Pills	59.84€ 56.99€	Buy
Viagra Super Active	100mg	90 + 10 Pills	165.61€ 157.72€	Buy
Viagra Generic	25mg	60 + 4 Pills	71.99€ 68.56€	Buy
Viagra Generic	100mg	180 + 8 Pills	199.37€ 189.88€	Buy
Viagra Generic	100mg	20 Pills	45.58€ 43.41€	Buy
Viagra Original	100mg	34 + 2 Pills	163.67€ 155.88€	Buy
Viagra Original	100mg	22 + 2 Pills	120.71€ 114.96€	Buy
Viagra Generic	150mg	90 + 6 Pills	147.18€ 140.17€	Buy
Viagra Generic	150mg	270 + 10 Pills	326.61€ 311.06€	Buy
Viagra Generic	100mg	120 + 6 Pills	149.50€ 142.38€	Buy
Viagra Professional	100mg	10 Pills	44.09€ 41.99€	Buy

In this subset, significant increases in SFQ28 Arousal Sensation domain score were seen vs the placebo group.

Country	Regulatory Body	Status	Notes
United States	FDA	Approved for research only	Not for medicinal use
EU	EMA	Under review	Pending approval
Canada	Health Canada	Approved	Sale restrictions
Australia	TGA	Not approved	Banned for sale

These patients also had a higher mean improvement in SFQ28 Desire and Orgasm domain scores, as well as significantly decreased sexual distress and interpersonal difficulties as assessed by FSDS-DAO questions 3, 5, and 10.2 “As more women speak openly about their sexual health, the need for research-backed solutions has never been greater,” said Irwin Goldstein, MD, director of San Diego Sexual Medicine in California and a founder of the International Society for the Study of Women’s Sexual Health in the news release. “Daré’s commitment to both clinical integrity and timely access ensures women who need it don’t have to wait to benefit from this innovation.”1 DARE to PLAY sildenafil cream now available for pre-order by prescription: First evidence-based topical arousal cream for women begins commercial rollout in select states via 503B outsourcing facility. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized controlled trial.

• The development of Viagra cream aims to improve convenience.
• It may allow for quicker libido response times.
• Compatibility with condom use varies; check labels.
• Some formulations are designed for extended release.
• Users with sensitive skin should opt for hypoallergenic versions.
• The safety profile of long-term topical use is not well-established.
• Dosage may be adjusted based on individual needs.
• Always follow storage and usage instructions carefully.
• Using too much can lead to unwanted side effects.
• Disclosure with a healthcare professional is recommended.

"With women, it has been viewed as more complicated ..

What does the research say?

We've found that it works well in perimenopausal and menopausal women as well! Pentoxifylline: Influences changes in blood flow and improves blood flow to genital tissue. One bottle of each, a 3-month supply, billed at $169.95. Menopause doesn’t mean saying goodbye to your sex life. Estrogen loss can cause dry vaginal skin, painful sex, and a dip in desire.

Full Text Sources

Estradiol Vaginal Cream restores moisture and improves elasticity. O-mazing Cream stimulates lubrication and increases blood flow, leading to more fulfilling orgasms. Together, they make sex feel good again! You’ll have unlimited access to your menopause-specialized doctor with your sexual health product subscription. “Management of Genitourinary Syndrome of Menopause in Women with or at High Risk for Breast Cancer.” Menopause, vol. but it's not." Today, doctors can begin prescribing a first-of-its-kind arousal cream for women. Daré Bioscience, a biotech company focused solely on women’s health innovations, launched DARE to PLAY™, a cream to improve women’s sexual health and desire.

HOW TO GET YOUR PRESCRIPTION

What is the best cream for erectile dysfunction? Erectile dysfunction creams and gels may seem great in theory, but few are available for purchase. Fortunately, though, there are many other ED treatments with plenty of satisfied customers. Here’s what to keep in mind when considering ED creams: The only FDA-authorized ED gel is Eroxon. Over-the-counter Eroxon is available without a prescription and works by cooling and heating the penis, stimulating the nerves to improve blood flow.

Formulated to work within 30 minutes

The only FDA-authorized ED gel is Eroxon. Many “natural” products are marketed for improving erectile function and enhancing sexual performance — but there’s very little proof they work. Since the FDA doesn’t test or approve these supplements in the same way it regulates medications, they may contain harmful ingredients. There are legit alternatives to erectile dysfunction creams and gels. While very few ED creams and gels are on the market, numerous safe and highly effective erectile dysfunction treatments are available. The product, which is now available in some states through prescription, is made with the same active ingredient as Viagra: sildenafil. Viagra was FDA-approved in 1998 to treat erectile dysfunction in men, and nearly thirty years later, momentum to create similar products for women has lagged far behind.

Medication Type	Interaction Effect	Advice
Nitrates	Severe hypotension (low blood pressure)	Avoid concurrent use
Alpha-blockers	Enhanced blood pressure-lowering effect	Monitor blood pressure
CYP3A4 Inhibitors	Increased plasma levels of sildenafil	Dose adjustment needed

At least one in five women will experience low libido or struggle with arousal during sex; for women in midlife, low libido is more common amid hormonal fluctuations.

If you're tired of uncertain quality and unproven options, you're not alone.

Therapy can also be helpful if your ED has psychological roots, like anxiety. Erectile dysfunction can be frustrating to deal with, but it is treatable. Learning more about ED and your treatment options is a solid first step in figuring it out. Check out our blog posts on the latest ED treatments, remedies for premature ejaculation (PE), and how to get hard. Our online platform can connect you with a healthcare professional today.

Though you cannot place an order quite yet...

SST completes Phase I trial of SST-6006 to treat erectile dysfunction in men. Alprostadil cream in the treatment of erectile dysfunction: clinical evidence and experience. Scoping review exploring advancements in topical agent therapies for erectile dysfunction. Alpostadil best viagra for men in cream — a new option of treating erectile dysfunctions in diabetes. Could the drug used to treat erectile dysfunction help women who have difficulties with arousal? “We knew from existing research that the same active ingredient in Viagra could have similar benefits for women, but when taken as a pill, it caused unwanted side effects,” CEO of Daré Bioscience Sabrina Johnson tells Flow Space. “So, we asked a simple question: what if we could deliver it differently?” The topical cream formulation works by increasing blood flow before a sexual activity by opening and relaxing blood vessels in the clitoris and vulva, where the cream is applied.

How does topical sildenafil cream work?

Nurnberg HG, Hensley PL, Heiman JR, Croft HA, Debattista C, Paine S. Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. “The 2020 Genitourinary Syndrome of Menopause viagra pfizer Position Statement of the North American Menopause Society.” Menopause, vol. Schoen C, Bachmann G. Sildenafil citrate for female sexual arousal disorder: a future possibility? Johnson hopes this launch marks a shift toward closing the gender desire gap.